Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses. Tread lightly interpreting polygenic tests of selection. Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies. Reduced signal for polygenic adaptation of height in UK Biobank. Penetrance and pleiotropy of polygenic risk scores for schizophrenia in 106,160 patients across four health care systems. Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases. Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps. Polygenic Risk Score Task Force of the International Common Disease Alliance. Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample the EU-GEI study. Multi-polygenic score approach to trait prediction. Complex trait prediction from genome data: contrasting EBV in livestock to PRS in humans: genomic prediction. CHD = coronary heart disease CRS = conventional risk score EHR = electronic health record GRS = genetic risk score LDL-C = serum calculated low density lipoprotein PHR = personal health record.Wray, N. d, The time course of statin use and lowering of LDL-C levels in CRS and GRS participants potentially mirrors significant changes in information seeking and sharing LDL-C decreased from baseline significantly more in GRS participants, due to higher statin use relative to CRS participants. c, Sharing radius (see Figure S3) at 3 months post-disclosure, with distribution skewed towards a maximum score Σ=4 for GRS participants. b, Information sharing at 3 months post-disclosure, with significant p-values (*P<0.05) for the mean difference between values at 3 and 6 months post-disclosure. a, Internet use and EHR/PHR access at baseline and/or 3 and 6 months after risk disclosure, with significant p-values (*P<0.05) for the mean difference between values at 3 and 6 months post-disclosure shared decision-making for statin initiation and documentation of subsequently lowered LDL-c levels in the chart are completed by or at 3 months post-disclosure, prior to observation of significant changes in information seeking and sharing survey responses between the CRS and GRS groups from 3 to 6 months post-disclosure. ![]() Six-month post-disclosure, genetic risk score participants were more likely than conventional risk score participants to visit a website to learn about CHD (odds ratio, 4.88 P=0.01), use the internet for information about how genetic factors affect CHD risk (OR, 2.11 P=0.04), access their CHD risk via a patient portal (OR, 2.99 P=0.01), and discuss their CHD risk with others (OR, 3.13 P=0.01), particularly their siblings (OR, 1.92 P=0.03), extended family (OR, 3.8 P=0.01), coworkers (OR, 2.42 P=0.03), and primary care provider (PCP OR, 2.00 P=0.03).ĭisclosure of a genetic risk score for CHD increased information seeking and sharing.Ĭoronary disease electronic health records genetic testing polymorphism, genetic. Information sharing was assessed post-disclosure. Surveys assessing information seeking were completed before and after risk disclosure. CHD risk was disclosed by a genetic counselor and then discussed with a physician. ![]() The MI-GENES study (Myocardial Infarction Genes) randomized participants (n=203) aged 45 to 65 years who were at intermediate CHD risk based on conventional risk factors and not on statins to receive their conventional risk score alone or also a genetic risk score based on 28 variants. We hypothesized that disclosing genetic risk for CHD to individuals influences information seeking and sharing. Whether disclosing genetic risk for coronary heart disease (CHD) to individuals influences information seeking and information sharing is not known.
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